Michael Purugganan

Michael Purugganan

Dorothy Schiff Professor of Genomics; Professor of Biology; Associate Director, Center for Genomics and Systems Biology
Ph.D. 1993 (Botany/Global Policy), University of Georgia; M.A. 1986 (Chemistry), Columbia; B.S. 1985 (Chemistry), University of the Philippines.

Office Address:
New York University
Department of Biology
Center for Genomics and Systems Biology
12 Waverly Place, Room 405
New York, NY 10003

Email:
Phone: (212) 992-9628
Fax: (212) 995-4015
List of Publications from Pubmed

List of citations from Google Scholar

Lab Homepage

Research

Evolutionary and ecological genomics of plant adaptations

We study the evolutionary forces that act in plant developmental networks at the species level, and in mapping and isolating genes that underlie natural variation in that are responsible for plant adaptation. We are also interested in exploring the “ecological transciptome” – the dynamic gene networks found in plants in ecological environments. This work combines concepts and techniques in evolutionary and quantitative genomics, developmental biology, evolutionary ecology, and computational biology.

Genetics of Plant Domestication

Crops are plant species that have evolved in a cultural context to provide food and other products for human society. Crop species are fascinating subjects for evolutionary study, since they are examples of species that have undergone rapid diversification under intense selection pressures. They also permit us to understand the dynamic interface between genetics, evolution and human culture. We are studying the evolution of genes in rice (Oryza sativa). By using tools of molecular and evolutionary genomics, these studies provide insights into the processes and mechanisms that accompany cultural selection on plant species during domestication events.

The Evolution of Multicellularity and Social Behaviour

The model protist Dictyostelium discoideum has been a model for the study of social biology as well as the evolution of multicellularity. We are integrating techniques and approaches in population genetics, genomics, systems biology and glycomics to study kin discrimination and recognition in this social microbe.

Funding: Work in my laboratory is funded by grants from the NSF Plant Genome Research program and the Population and Evolutionary Processes program.

Collaborators: Carlos Bustamante (Stanford), Barbara Schaal (Washington University), Scott Jackson (University of Georgia), Richard Bonneau (NYU), Kourosh-Salehi Ashtiani (NYU Abu Dhabi), Endang Septiningsih (International Rice Research Institute)

Biosketch

Dr. Michael Purugganan received his B.S. in Chemistry from the University of the Philippines (1985), an M.A. from Columbia University (1986) and a Ph.D. in Botany with a Global Policy minor at the University of Georgia (1993). After obtaining his Ph.D., he did postdoctoral research as an Alfred P. Sloan Molecular Evolution Fellow at the University of California in San Diego, studying the evolution of development (1993-1995). Dr. Purugganan is a leader in the field of evolutionary and ecological genomics and his work focuses on identifying the molecular basis for evolutionary adaptations that occur in nature. Prior to joining the NYU faculty in 2006, he was the William Neal Reynolds Distinguished Professor of Genetics at North Carolina State University, where he also won the Outstanding Faculty Research Award and the Sigma Xi Research Prize. He is the recipient of an Alfred P. Sloan Foundation Young Investigator Award, a Guggenheim Fellowship, is a Kavli Fellow, and in 2005 was elected a Fellow of the American Association for the Advancement of Science. Dr. Purugganan is on the editorial boards of the journals Genome Biology and Evolution, Molecular Ecology, Trends in Plant Science and the Annual Review of Ecology, Evolution and Systematics.

Areas of Research/Interest

Plant Evolutionary Genomics

External Affiliations

American Association for the Advancement of Science; Genetics Society of America and Society for Molecular Biology and Evolution

Fellowships/Honors

Guggenheim Fellow (2006 - 2007); Fellow, American Association for the Advancement of Science (Elected 2005); Sloan Young Investigator (1997-2002)

Publications

Genome-wide patterns of Arabidopsis gene expression in nature.
PLoS Genet   (2012 Apr)
Richards CL, Rosas U, Banta J, Bhambhra N, Purugganan MD
The plant proteome folding project: structure and positive selection in plant protein families.
Genome Biol Evol   (2012)
Pentony MM, Winters P, Penfold-Brown D, Drew K, Narechania A, DeSalle R, Bonneau R, Purugganan MD
Natural selection in gene-dense regions shapes the genomic pattern of polymorphism in wild and domesticated rice.
Mol Biol Evol   (2012 Feb)
Flowers JM, Molina J, Rubinstein S, Huang P, Schaal BA, Purugganan MD
Levels and patterns of nucleotide variation in domestication QTL regions on rice chromosome 3 suggest lineage-specific selection.
PLoS One   (2011)
Xie X, Molina J, Hernandez R, Reynolds A, Boyko AR, Bustamante CD, Purugganan MD
Molecular evidence for a single evolutionary origin of domesticated rice.
Proc Natl Acad Sci U S A   (2011 May 17)
Molina J, Sikora M, Garud N, Flowers JM, Rubinstein S, Reynolds A, Huang P, Jackson S, Schaal BA, Bustamante CD, Boyko AR, Purugganan MD
The cooperative amoeba: Dictyostelium as a model for social evolution.
Trends Genet   (2011 Feb)
Li SI, Purugganan MD
Plant phenotypic plasticity in a changing climate.
Trends Plant Sci   (2010 Dec)
Nicotra AB, Atkin OK, Bonser SP, Davidson AM, Finnegan EJ, Mathesius U, Poot P, Purugganan MD, Richards CL, Valladares F, van Kleunen M
Migration, isolation and hybridization in island crop populations: the case of Madagascar rice.
Mol Ecol   (2010 Nov)
Mather KA, Molina J, Flowers JM, Rubinstein S, Rauh BL, Lawton-Rauh A, Caicedo AL, McNally KL, Purugganan MD
Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.
Lupus   (2010 Oct)
Ardoin SP, Schanberg LE, Sandborg C, Yow E, Barnhart HX, Mieszkalski K, Ilowite NT, von Scheven E, Eberhard A, Levy DM, Kimura Y, Silverman E, Bowyer SL, Punaro L, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung LK, Imundo L, Soep JB, Reed AM
Archaeological data reveal slow rates of evolution during plant domestication.
Evolution   (2011 Jan)
Purugganan MD, Fuller DQ
Variation, sex, and social cooperation: molecular population genetics of the social amoeba Dictyostelium discoideum.
PLoS Genet   (2010 Jul)
Flowers JM, Li SI, Stathos A, Saxer G, Ostrowski EA, Queller DC, Strassmann JE, Purugganan MD
MicroRNAs in plants: Possible contributions to phenotypic diversity.
Plant Signal Behav   (2008 Oct)
Ehrenreich IM, Purugganan M
Population genomics of the Arabidopsis thaliana flowering time gene network.
Mol Biol Evol   (2009 Nov)
Flowers JM, Hanzawa Y, Hall MC, Moore RC, Purugganan MD
A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana.
PLoS Genet   (2009 Jul)
Kover PX, Valdar W, Trakalo J, Scarcelli N, Ehrenreich IM, Purugganan MD, Durrant C, Mott R
Candidate gene association mapping of Arabidopsis flowering time.
Genetics   (2009 Sep)
Ehrenreich IM, Hanzawa Y, Chou L, Roe JL, Kover PX, Purugganan MD
Functional and geographical differentiation of candidate balanced polymorphisms in Arabidopsis thaliana.
Mol Ecol   (2009 Jul)
Reininga JM, Nielsen D, Purugganan MD
The nature of selection during plant domestication.
Nature   (2009 Feb 12)
Purugganan MD, Fuller DQ
Complex rearrangements lead to novel chimeric gene fusion polymorphisms at the Arabidopsis thaliana MAF2-5 flowering time gene cluster.
Mol Biol Evol   (2009 Mar)
Caicedo AL, Richards C, Ehrenreich IM, Purugganan MD
The evolution of plant genomes: scaling up from a population perspective.
Curr Opin Genet Dev   (2008 Dec)
Flowers JM, Purugganan MD
A conserved mutation in an ethylene biosynthesis enzyme leads to andromonoecy in melons.
Science   (2008 Aug 8)
Boualem A, Fergany M, Fernandez R, Troadec C, Martin A, Morin H, Sari MA, Collin F, Flowers JM, Pitrat M, Purugganan MD, Dogimont C, Bendahmane A
Sequence variation of MicroRNAs and their binding sites in Arabidopsis.
Plant Physiol   (2008 Apr)
Ehrenreich IM, Purugganan MD
Independent origins of self-compatibility in Arabidopsis thaliana.
Mol Ecol   (2008 Jan)
Shimizu KK, Shimizu-Inatsugi R, Tsuchimatsu T, Purugganan MD
Molecular phylogeography of domesticated barley traces expansion of agriculture in the Old World.
Genetics   (2007 Nov)
Saisho D, Purugganan MD
The extent of linkage disequilibrium in rice (Oryza sativa L.).
Genetics   (2007 Dec)
Mather KA, Caicedo AL, Polato NR, Olsen KM, McCouch S, Purugganan MD
Genome-wide patterns of nucleotide polymorphism in domesticated rice.
PLoS Genet   (2007 Sep)
Caicedo AL, Williamson SH, Hernandez RD, Boyko A, Fledel-Alon A, York TL, Polato NR, Olsen KM, Nielsen R, McCouch SR, Bustamante CD, Purugganan MD
Diversity and divergence patterns in regulatory genes suggest differential gene flow in recently derived species of the Hawaiian silversword alliance adaptive radiation (Asteraceae).
Mol Ecol   (2007 Oct)
Lawton-Rauh A, Robichaux RH, Purugganan MD
Genetics of microenvironmental canalization in Arabidopsis thaliana.
Proc Natl Acad Sci U S A   (2007 Aug 21)
Hall MC, Dworkin I, Ungerer MC, Purugganan M
The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping.
Genetics   (2007 Jun)
Ehrenreich IM, Stafford PA, Purugganan MD
Fitness effects associated with the major flowering time gene FRIGIDA in Arabidopsis thaliana in the field.
Am Nat   (2007 May)
Korves TM, Schmid KJ, Caicedo AL, Mays C, Stinchcombe JR, Purugganan MD, Schmitt J
Genomic variation in rice: genesis of highly polymorphic linkage blocks during domestication.
PLoS Genet   (2006 Nov 17)
Tang T, Lu J, Huang J, He J, McCouch SR, Shen Y, Kai Z, Purugganan MD, Shi S, Wu CI
Evolutionary patterns in the antR-Cor gene in the dwarf dogwood complex (Cornus, Cornaceae).
Genetica   (2007 May)
Fan C, Xiang QY, Remington DL, Purugganan MD, Wiegmann BM
The molecular genetic basis of plant adaptation.
Am J Bot   (2006 Jul)
Ehrenreich IM, Purugganan MD
Epialleles via DNA methylation: consequences for plant evolution.
Trends Ecol Evol   (2004 Jun)
Kalisz S, Purugganan MD
Comparative sequencing of plant genomes: choices to make.
Plant Cell   (2006 May)
Jackson S, Rounsley S, Purugganan M
Molecular population genetics and phenotypic diversification of two populations of the thermophilic cyanobacterium Mastigocladus laminosus.
Appl Environ Microbiol   (2006 Apr)
Miller SR, Purugganan MD, Curtis SE
Selection under domestication: evidence for a sweep in the rice waxy genomic region.
Genetics   (2006 Jun)
Olsen KM, Caicedo AL, Polato N, McClung A, McCouch S, Purugganan MD
Vernalization sensitivity in Arabidopsis thaliana (Brassicaceae): the effects of latitude and FLC variation.
Am J Bot   (2005 Oct)
Stinchcombe JR, Caicedo AL, Hopkins R, Mays C, Boyd EW, Purugganan MD, Schmitt J
Evolutionary and ecological genomics of Arabidopsis.
Plant Physiol   (2005 Jun)
Shimizu KK, Purugganan MD
Comparative plant genomics. Frontiers and prospects.
Plant Physiol   (2005 Jun)
Caicedo AL, Purugganan MD
High-diversity genes in the Arabidopsis genome.
Genetics   (2005 Aug)
Cork JM, Purugganan MD
The evolutionary dynamics of plant duplicate genes.
Curr Opin Plant Biol   (2005 Apr)
Moore RC, Purugganan MD
The molecular population genetics of the Tomato spotted wilt virus (TSWV) genome.
Mol Ecol   (2005 Jan)
Tsompana M, Abad J, Purugganan M, Moyer JW
Darwinian selection on a selfing locus.
Science   (2004 Dec 17)
Shimizu KK, Cork JM, Caicedo AL, Mays CA, Moore RC, Olsen KM, Ruzsa S, Coop G, Bustamante CD, Awadalla P, Purugganan MD
Heterogeneous evolution of the Myc-like Anthocyanin regulatory gene and its phylogenetic utility in Cornus L. (Cornaceae).
Mol Phylogenet Evol   (2004 Dec)
Fan C, Purugganan MD, Thomas DT, Wiegmann BM, Xiang JQ
Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait.
Proc Natl Acad Sci U S A   (2004 Nov 2)
Caicedo AL, Stinchcombe JR, Olsen KM, Schmitt J, Purugganan MD
The evolution of plant development.
Am J Bot   (2004 Oct)
Friedman WE, Moore RC, Purugganan MD
Molecular population genetics of redundant floral-regulatory genes in Arabidopsis thaliana.
Mol Biol Evol   (2005 Jan)
Moore RC, Grant SR, Purugganan MD
Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles.
Genetics   (2004 Jul)
Olsen KM, Halldorsdottir SS, Stinchcombe JR, Weinig C, Schmitt J, Purugganan MD
The evolution of molecular genetic pathways and networks.
Bioessays   (2004 May)
Cork JM, Purugganan MD
A latitudinal cline in flowering time in Arabidopsis thaliana modulated by the flowering time gene FRIGIDA.
Proc Natl Acad Sci U S A   (2004 Mar 30)
Stinchcombe JR, Weinig C, Ungerer M, Olsen KM, Mays C, Halldorsdottir SS, Purugganan MD, Schmitt J
The early stages of duplicate gene evolution.
Proc Natl Acad Sci U S A   (2003 Dec 23)
Moore RC, Purugganan MD
Genotype-environment interactions at quantitative trait loci affecting inflorescence development in Arabidopsis thaliana.
Genetics   (2003 Sep)
Ungerer MC, Halldorsdottir SS, Purugganan MD, Mackay TF
Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana.
Genetics   (2003 Sep)
Weinig C, Dorn LA, Kane NC, German ZM, Halldorsdottir SS, Ungerer MC, Toyonaga Y, Mackay TF, Purugganan MD, Schmitt J
Patterns of nucleotide variation in homoeologous regulatory genes in the allotetraploid Hawaiian silversword alliance (Asteraceae).
Mol Ecol   (2003 May)
Lawton-Rauh A, Robichaux RH, Purugganan MD
Merging ecology, molecular evolution, and functional genetics.
Mol Ecol   (2003 May)
Purugganan M, Gibson G
Molecular population genetics of the Arabidopsis CLAVATA2 region. The genomic scale of variation and selection in a selfing species.
Genetics   (2003 Mar)
Shepard KA, Purugganan MD
Selection on rapidly evolving proteins in the Arabidopsis genome.
Genetics   (2003 Feb)
Barrier M, Bustamante CD, Yu J, Purugganan MD
Novel loci control variation in reproductive timing in Arabidopsis thaliana in natural environments.
Genetics   (2002 Dec)
Weinig C, Ungerer MC, Dorn LA, Kane NC, Toyonaga Y, Halldorsdottir SS, Mackay TF, Purugganan MD, Schmitt J
Molecular evidence on the origin and evolution of glutinous rice.
Genetics   (2002 Oct)
Olsen KM, Purugganan MD
GAI homologues in the Hawaiian silversword alliance (Asteraceae-Madiinae): molecular evolution of growth regulators in a rapidly diversifying plant lineage.
Mol Biol Evol   (2002 Sep)
Remington DL, Purugganan MD
Contrasting evolutionary forces in the Arabidopsis thaliana floral developmental pathway.
Genetics   (2002 Apr)
Olsen KM, Womack A, Garrett AR, Suddith JI, Purugganan MD
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase.
Mol Cell Biol   (2002 May)
Huye LE, Purugganan MM, Jiang MM, Roth DB
Distinct and opposite diversifying activities of terminal transferase splice variants.
Nat Immunol   (2002 May)
Thai TH, Purugganan MM, Roth DB, Kearney JF
The cost of inbreeding in Arabidopsis.
Nature   (2002 Apr 4)
Bustamante CD, Nielsen R, Sawyer SA, Olsen KM, Purugganan MD, Hartl DL
Quantitative trait loci for inflorescence development in Arabidopsis thaliana.
Genetics   (2002 Mar)
Ungerer MC, Halldorsdottir SS, Modliszewski JL, Mackay TF, Purugganan MD
Map-based cloning of quantitative trait loci: progress and prospects.
Genet Res   (2001 Dec)
Remington DL, Ungerer MC, Purugganan MD
The genetics of plant morphological evolution.
Curr Opin Plant Biol   (2002 Feb)
Shepard KA, Purugganan MD
Accelerated regulatory gene evolution in an adaptive radiation.
Proc Natl Acad Sci U S A   (2001 Aug 28)
Barrier M, Robichaux RH, Purugganan MD
Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase.
Nucleic Acids Res   (2001 Apr 1)
Purugganan MM, Shah S, Kearney JF, Roth DB
Quantitative trait loci for floral morphology in Arabidopsis thaliana.
Genetics   (2000 Nov)
Juenger T, Purugganan M, Mackay TF
The molecular population genetics of regulatory genes.
Mol Ecol   (2000 Oct)
Purugganan MD
Variation and selection at the CAULIFLOWER floral homeotic gene accompanying the evolution of domesticated Brassica oleracea.
Genetics   (2000 Jun)
Purugganan MD, Boyles AL, Suddith JI
Molecular evolution of flower development.
Trends Ecol Evol   (2000 Apr)
Lawton-Rauh AL, Alvarez-Buylla ER, Purugganan MD
Interspecific evolution in plant microsatellite structure.
Gene   (2000 Jan 4)
Barrier M, Friar E, Robichaux R, Purugganan M
Duplication of the Brassica oleracea APETALA1 floral homeotic gene and the evolution of domesticated cauliflower.
J Hered   (1999 Sep-Oct)
Lowman AC, Purugganan MD
Patterns of molecular evolution among paralogous floral homeotic genes.
Mol Biol Evol   (1999 Aug)
Lawton-Rauh AL, Buckler ES 4th, Purugganan MD
Interspecific hybrid ancestry of a plant adaptive radiation: allopolyploidy of the Hawaiian silversword alliance (Asteraceae) inferred from floral homeotic gene duplications.
Mol Biol Evol   (1999 Aug)
Barrier M, Baldwin BG, Robichaux RH, Purugganan MD
Molecular population genetics of floral homeotic loci. Departures from the equilibrium-neutral model at the APETALA3 and PISTILLATA genes of Arabidopsis thaliana.
Genetics   (1999 Feb)
Purugganan MD, Suddith JI
The molecular evolution of development.
Bioessays   (1998 Sep)
Purugganan MD
V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells.
Nucleic Acids Res   (1998 Aug 15)
Han JO, Erskine LA, Purugganan MM, Stamato TD, Roth DB
Molecular population genetics of the Arabidopsis CAULIFLOWER regulatory gene: nonneutral evolution and naturally occurring variation in floral homeotic function.
Proc Natl Acad Sci U S A   (1998 Jul 7)
Purugganan MD, Suddith JI
Cellular localization of Arabidopsis xyloglucan endotransglycosylase-related proteins during development and after wind stimulation.
Plant Physiol   (1997 Dec)
Antosiewicz DM, Purugganan MM, Polisensky DH, Braam J
The Arabidopsis TCH4 xyloglucan endotransglycosylase. Substrate specificity, pH optimum, and cold tolerance.
Plant Physiol   (1997 Sep)
Purugganan MM, Braam J, Fry SC
The evolution of the conserved ATPase domain (CAD): reconstructing the history of an ancient protein module.
J Mol Evol   (1997 Nov)
Swaffield JC, Purugganan MD
The MADS-box floral homeotic gene lineages predate the origin of seed plants: phylogenetic and molecular clock estimates.
J Mol Evol   (1997 Oct)
Purugganan MD
Plant responses to environmental stress: regulation and functions of the Arabidopsis TCH genes.
Planta   (1997)
Braam J, Sistrunk ML, Polisensky DH, Xu W, Purugganan MM, Antosiewicz DM, Campbell P, Johnson KA
Life in a changing world: TCH gene regulation of expression and responses to environmental signals.
Physiol Plant   (1996 Dec)
Braam J, Sistrunk ML, Polisensky DH, Xu W, Purugganan MM, Antosiewicz DM, Campbell P, Johnson KA
Evolution of development: molecules, mechanisms and phylogenetics.
Trends Ecol Evol   (1996)
Purugganan MD
Arabidopsis TCH4, regulated by hormones and the environment, encodes a xyloglucan endotransglycosylase.
Plant Cell   (1995 Oct)
Xu W, Purugganan MM, Polisensky DH, Antosiewicz DM, Fry SC, Braam J
Molecular evolution of flower development: diversification of the plant MADS-box regulatory gene family.
Genetics   (1995 May)
Purugganan MD, Rounsley SD, Schmidt RJ, Yanofsky MF
Transposon signatures: species-specific molecular markers that utilize a class of multiple-copy nuclear DNA.
Mol Ecol   (1995 Apr)
Purugganan MD, Wessler SR
Molecular evolution of magellan, a maize Ty3/gypsy-like retrotransposon.
Proc Natl Acad Sci U S A   (1994 Nov 22)
Purugganan MD, Wessler SR
Molecular evolution of the plant R regulatory gene family.
Genetics   (1994 Nov)
Purugganan MD, Wessler SR
Arabidopsis TCH3 encodes a novel Ca2+ binding protein and shows environmentally induced and tissue-specific regulation.
Plant Cell   (1994 Nov)
Sistrunk ML, Antosiewicz DM, Purugganan MM, Braam J
Transposable elements as introns: evolutionary connections.
Trends Ecol Evol   (1993 Jul)
Purugganan MD
Alternative splicing induced by insertion of retrotransposons into the maize waxy gene.
Plant Cell   (1992 Jul)
Varagona MJ, Purugganan M, Wessler SR
The splicing of transposable elements and its role in intron evolution.
Genetica   (1992)
Purugganan M, Wessler S
Filler DNA is associated with spontaneous deletions in maize.
Proc Natl Acad Sci U S A   (1990 Nov)
Wessler S, Tarpley A, Purugganan M, Spell M, Okagaki R
The fractal nature of RNA secondary structure.
Naturwissenschaften   (1989 Oct)
Purugganan MD
Accelerated electron transfer between metal complexes mediated by DNA.
Science   (1988 Sep 23)
Purugganan MD, Kumar CV, Turro NJ, Barton JK

Email update requests to fas.bio.computing@nyu.edu .