Michael Carrozza

Michael J Carrozza

Clinical Assistant Professor of Biology

Ph.D 1999 University of Pittsburgh School of Medicine, B.S. 1989 University of Pittsburgh

Office Address: 

New York University
Department of Biology
1009 Silver Center
100 Washington Square East
New York, NY 10003-6688

Phone: 

212-992-6961

Fax: 

212-995-4015

Areas of Research/Interest: 

Chromatin, Transcription, DNA damage and repair

List of citations from Google Scholar

Selected Works:

Sardiu, M. E., J. M. Gilmore, M. J. Carrozza, B. Li, J. L. Workman, L. Florens, and M. P. Washburn.  (2009).
Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics.
PloS one  4:e7310.

Carrozza, M. J., D. F. Stefanick, J. K. Horton, P. S. Kedar and S. H. Wilson.  (2009)
PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.
DNA Repair.  8:1264-1272

GutiĆ©rrez, J. L., M. Chandy, M. J. Carrozza and J. L. Workman.  (2007)
Activation domains drive nucleosome eviction by SWI/SNF.
EMBO Journal. 26:730-740.

Carrozza, M. J., B. Li, L. Florens, S. K. Swanson, K. K. Lee, W.-J. Shia, S. Anderson, J. Yates, M. P. Washburn and J. L. Workman.  (2005)
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.
Cell.  123:581-592.
 Cited in 270 publications (ISI Web of Science) and Faculty of 1000.

Carrozza, M. J., L. Florens, S. K. Swanson, W. -J. Shia, S. Anderson, J. Yates, M. P. Washburn and J. L. Workman.  (2005)
Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.
Biochimica et Biophysica Acta-Gene Structure and Expression.  1731:77-87.

Vermeulan, M., M. J. Carrozza, E. Lasonder, J. L. Workman, C. Logie and H. G. Stunnenberg.  (2004)
In vitro targeting reveals intrinsic histone tail specificity of the Sin3/HDAC and N-CoR/SMRT co-repressor complexes.
Molecular and Cellular Biology  24:2364-2372.

Meehan, W. J., R. S. Samant, J. E. Hopper, M. J. Carrozza, L. A. Shevde, J. L. Workman, K. A. Eckert, M. F. Verderame and D. R. Welch.  (2004)
The BRMS1 metastasis suppressor forms complexes with RBP1 and the mSin3 histone deacetylase complex and represses transcription.
Journal of Biological Chemistry.  279:1562-1569.

Hassan, A. H., P. Prochasson, K. E. Neely, S. C. Galasinski, M. Chandy, M. J. Carrozza and J. L. Workman.  (2002)
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.
Cell.  111:369-379.

Carrozza, M. J., S. John, A. K. Sil, J. E. Hopper and J. L. Workman.  (2002)
Gal80 confers specificity on HAT complex interactions with activators.
Journal of Biological Chemistry.  277:24648-24652.

Brown, C.E., L. Howe, K. Sausa, S. Alley, M. J. Carrozza, S. Tan and Workman, J.L.  (2001)
The ATM related cofactor Tra1p is an essential direct target of transcription activators in the SAGA and NuA4 complexes.
Science.  292:2333-2337.

Lechner T., M. J. Carrozza, Y. Yu, P. A. Grant, A. Eberharter, D. Vannier, G. Brosch, D. J. Stillman, D. Shore and J. L. Workman.  (2000)
Sds3 (Suppressor of Defective Silencing 3) is an integral component of the yeast Sin3-Rpd3 HDAC complex required for histone deacetylase activity.  Journal of Biological Chemistry.  275:40961-40966.

Carrozza, M. J. and N. A. DeLuca.  (1998)
The high mobility group protein 1 is a coactivator of herpes simplex virus ICP4 in vitro.
Journal of Virology.  72:6752-6757.

Carrozza, M. J. and N. A. DeLuca.  (1996)
Interaction of the viral activator protein ICP4 with TFIID through TAF250.
Molecular and Cellular Biology.  16:3085-3093.

Osifchin, N. E., D. Jiang, N. Ohtani-Fujita, T. Fujita, M. J. Carrozza, S-J. Kim, T. Sakai and P. D.Robbins.  (1994)
Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.
Journal of Biological Chemistry.  269:6383-6389.

Reviews

Ercan, S. and M. J. Carrozza.  (2008)
  Histone Variants and Nucleosome Occupancy, Chapter 5. p. 127-151.
  In Tost, J. (ed.), Epigenetics. Caister Academic Press, Norwich, U.K.

Ercan, S., M. J. Carrozza and J. L. Workman.  (2004)
Global nucleosome distribution and the regulation of transcription in yeast.
Genome Biology.  5:243.

Carrozza, M. J.,T. Kusch and J. L. Workman.  (2003)
Repairing nucleosomes during transcription.
Nature Structural Biology.  10:879-880.

Carrozza, M. J., R. T. Utley, J. L. Workman and J. Cote.  (2003)
The diverse functions of histone acetyltransferase complexes.
Trends in Genetics.  19:321-329.

Methods

Florens, L., M. J. Carrozza, S. K. Swanson, M. Fournier, M. K. Coleman, J. L. Workman and M. P. Washburn. (2006)
Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors.  Methods.  40:303-311.

Carrozza, M. J., A. H. Hassan and J. L. Workman.  (2003)
Assay of activator recruitment of chromatin-modifying complexes.
Methods in Enzymology  371:536-544.

Abmayr, S. M., M. J. Carrozza and Workman, J. L.  (2001)
Preparation of nuclear and cytoplasmic extracts from mammalian cells, Unit 12.3.
In S.J. Enna, M. Williams, J. W. Ferkany, T. Kenakin, Roger D. Porsolt, J. P. Sullivan (ed.), Current Protocols in Pharmacology. John Wiley & Sons, Inc., New York, New York

Updated on 01/23/2014