Elodie Ghedin headshot

Elodie Ghedin

Professor of Biology, Public Health; Faculty Director of Genomic Sequencing

Ph.D. 1998 (Molecular Parasitology) McGill University, Canada; M. Sc.1993 (Environmental Sciences), Université du Québec à Montreal; B.Sc. 1989 (Biology). McGill University, Canada

Office Address: 

New York University
Department of Biology
1009 Silver Center
100 Washington Square East
New York, NY 10003-6688

Lab Homepage: 

https://wp.nyu.edu/ghedinlab/

Areas of Research/Interest: 

Evolutionary genomics of infectious agents; neglected tropical diseases; microbiome and virus metagenomic studies.

List of Publications from Pubmed

List of citations from Google Scholar

Research:

The focus of our laboratory is on defining genomic characteristics of human parasites and other pathogens. Our research is multidisciplinary and draws upon the tools of genomics, molecular virology, and computational biology. Projects include the study of influenza virus evolution and emergence, the analysis of the microbiome and mycobiome (fungal microbiota) associated with the pathogenesis of lung obstruction and emphysema in HIV patients, and the characterization of endosymbiotic interactions between filarial worms and Wolbachia.

Objectives:

To identify the extent of intra- and inter-host microparasite (viruses and bacteria) diversity within the context of transmission and virulence, and parse the relationship between microbial ecology in the respiratory tract and disease progression;
To develop and apply new genomic methods to study microbial pathogens, particularly the associations with their hosts in the context of human disease;
To elucidate the molecular basis behind the adaptation of macroparasites, such as worms, to niches in their human hosts.

Affiliated with other departments or programs:

Public Health

External Affiliations:

Adjunct, Department of Computational & Systems Biology, University of Pittsburgh School of Medicine

Fellowships/Honors:

University of Pittsburgh Chancellor’s Distinguished Research Award, Junior Scholar (2010)
MacArthur Fellow (2011)
Kavli Frontiers of Science Fellow (2012)

Selected Works:


Rogers MB, Song T, Sebra R, Greenbaum BD, Hamelin ME, Fitch A, Twaddle A, Cui L, Holmes EC, Boivin G, Ghedin E. (2015) Intrahost dynamics of antiviral resistance in influenza A virus reflect complex patterns of segment linkage, reassortment, and natural selection.
MBio. 6(2). pii: e02464-14.

Cui L, Lucht L, Tipton L, Rogers MB, Fitch A, Kessinger C, Camp D, Kingsley L, Leo N, Greenblatt RM, Fong S, Stone S, Dermand JC, Kleerup EC, Huang L, Morris A, Ghedin E. (2015) Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease. Am J Respir Crit Care Med. 191(8):932-42.

Bringaud F, Rogers M, Ghedin E. (2015) Identification and analysis of ingi-related retroposons in the trypanosomatid genomes. Methods Mol Biol. 1201:109-22.

Ghedin E. (2014) Panning for molecular gold in whipworm genomes.
Nat Genet. 46(7):661-3.

Lustigman S, Melnikow E, Anand SB, Contreras A, Nandi V, Liu J, Bell A, Unnasch TR, Rogers MB, Ghedin E. (2014) Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia. Int J Parasitol Drugs Drug Resist. 4(3):267-77.

Kerr PJ, Rogers MB, Fitch A, Depasse JV, Cattadori IM, Twaddle AC, Hudson PJ, Tscharke DC, Read AF, Holmes EC, Ghedin E. (2013) Genome scale evolution of myxoma virus (MYXV) reveals host-pathogen adaptation and rapid geographic spread. J Virol. 87(23):12900-15

Cui L, Morris A and Ghedin E. (2013). Characterizing the Human Mycobiome in Health and Disease. Genome Medicine. Review. 5(7):63.

Min J-Y, Santos C, Fitch A, Twaddle A, Toyoda Y, DePasse JV, Ghedin E, Subbarao K. (2013) Mammalian adaptation of the PB2 gene of avian H5N1 influenza virus. J Virol. 87(19):10884-8

Saira K, Lin X, DePasse  JV, Halpin R, Twaddle A, Stockwell T, Angus B, Cozzi-Lepri A, Delfino M, Dugan V, Dwyer DE, Freiberg M, Horban A, Losso M, Lynfield R, Wentworth DN, Holmes EC, Davey R, Wentworth D, Ghedin E. (2013) Sequence analysis of in vivo defective-interfering (DI)-like RNA of influenza A H1N1 pandemic virus. J Virol. 87(14):8064-74

Kerr PJ, Ghedin E, DePasse JV, Fitch A, Cattadori I, Hudson PJ, Tscharke DC, Read AF, Holmes EC. (2012) The evolutionary history and attenuation of myxoma virus on two continents. PLoS Pathogens 8(10):e1002950

Ghedin E, Holmes EC, DePasse JV, Pinilla LT, Fitch A, Hamelin M-E, Papenburg J, Boivin G. (2012) Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission. J Infect Dis 206(10):1504-11.

Ghedin E, Wang S, Spiro D, et al. (2007) Draft genome of the filarial nematode parasite Brugia malayi. Science. 317(5845):1756-60.



Updated on 08/30/2016