Professor of Biology, Public Health; Faculty Director of Genomic Sequencing
Ph.D. 1998 (Molecular Parasitology) McGill University, Canada; M. Sc.1993 (Environmental Sciences), Université du Québec à Montreal; B.Sc. 1989 (Biology). McGill University, Canada
|New York University|
|Department of Biology|
|1009 Silver Center|
|100 Washington Square East|
|New York, NY 10003-6688|
Research:The focus of our laboratory is on defining genomic characteristics of human parasites and other pathogens. Our research is multidisciplinary and draws upon the tools of genomics, molecular virology, and computational biology. Projects include the study of influenza virus evolution and emergence, the analysis of the microbiome and mycobiome (fungal microbiota) associated with the pathogenesis of lung obstruction and emphysema in HIV patients, and the characterization of endosymbiotic interactions between filarial worms and Wolbachia.
Objectives:To identify the extent of intra- and inter-host microparasite (viruses and bacteria) diversity within the context of transmission and virulence, and parse the relationship between microbial ecology in the respiratory tract and disease progression;
To develop and apply new genomic methods to study microbial pathogens, particularly the associations with their hosts in the context of human disease;
To elucidate the molecular basis behind the adaptation of macroparasites, such as worms, to niches in their human hosts.
Affiliated with other departments or programs:
Adjunct, Department of Computational & Systems Biology, University of Pittsburgh School of Medicine
University of Pittsburgh Chancellor’s Distinguished Research Award, Junior Scholar (2010)
MacArthur Fellow (2011)
Kavli Frontiers of Science Fellow (2012)
|Rogers MB, Song T, Sebra R, Greenbaum BD, Hamelin ME, Fitch A, Twaddle A, Cui L, Holmes EC, Boivin G, Ghedin E. (2015) Intrahost
dynamics of antiviral resistance in influenza A virus reflect complex
patterns of segment linkage, reassortment, and natural selection.|
MBio. 6(2). pii: e02464-14.
|Cui L, Lucht L, Tipton L, Rogers MB, Fitch A, Kessinger C, Camp D,
Kingsley L, Leo N, Greenblatt RM, Fong S, Stone S, Dermand JC, Kleerup
EC, Huang L, Morris A, Ghedin E. (2015) Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease. Am J Respir Crit Care Med. 191(8):932-42.|
|Kerr PJ, Rogers MB, Fitch A, Depasse JV, Cattadori IM, Twaddle AC, Hudson PJ, Tscharke DC, Read AF, Holmes EC, Ghedin E. (2013) Genome scale evolution of myxoma virus (MYXV) reveals host-pathogen adaptation and rapid geographic spread. J Virol. 87(23):12900-15|
|Saira K, Lin X, DePasse JV, Halpin R, Twaddle A, Stockwell T, Angus B,
Cozzi-Lepri A, Delfino M, Dugan V, Dwyer DE, Freiberg M, Horban A, Losso
M, Lynfield R, Wentworth DN, Holmes EC, Davey R, Wentworth D, Ghedin E.
(2013) Sequence analysis of in vivo defective-interfering (DI)-like RNA of influenza A H1N1 pandemic virus. J Virol. 87(14):8064-74|
Updated on 08/30/2016